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451 ESMTP MailEnable Service temporarily refused connection at 03/21/11 11:13:11 from IP 128.1.1.1) because the server is too busy.

To resolve this issue, increase the Max Inbound Connections of the SMTP service. 

MailEnable Administration Program -> servers -> localhost ->

connectors -> SMTP Properties -> Inbound TAB -> Maximum number of concurrent connections.